The effect of dietary fat supplements on the activity of palmitic and stearic acid desaturases based on the results of a study of the fatty acid composition of neutral lipids in blood serum and liver of rats receiving a fat-free diet

Background. Desaturase enzymes are involved in the formation of monoenoic acids from saturated fatty acids. One such enzyme is stearyl-CoA-desaturase (SCD1), which converts stearic acid to oleic acid. The aim this work was determine effect edible fats with different compositions on SCD1 activity.
 Methods. High linoleic sunflower oil (HLSO), high (HOSO) and palm (PO) were used. rats fed for 30 days a semi-synthetic diet that did not contain any (FFD) fat diets containing 5 % each above oils. In animals, lipids extracted serum liver divided into 3 fractions: neutral (NL), phospholipids (PL), free (FFA).
 composition fraction determined by gas chromatography. SCD18 activity C18:1 n-9/C18:0 ‒ ratio, SCD16 C16:1 n-7/C16:0 ratio.
 Results. A higher found NL fraction, significantly exceeds SCD16. decrease content C16:0, C18:0 blood shown. decreases diets­, while does decrease, even increases consumption HOSO.­
 Conclusions. To activity, it advisable use C18:1/C18:0 ratio terms level fraction. Fatty inhibits HOSO activity.